A review published this month (May 2025) looks at the effect of PRP on large joint osteoarthritis over time and finds that more is better.

A recently published meta-analysis of the last 60 years of research examines the effectiveness of PRP and cortisone in treating knee osteoarthritis. Unsurprisingly, and in line with the whole of the scientific literature, PRP was shown to be superior to cortisone for knee osteoarthritis pain with less side effects.

The study found that MFAT could provide significant pain relief and improve joint functionality compared to steroids and a saline injection.